IndraLab

Statements

OTULIN increases the amount of Ubiquitin. 2 / 2
1 | 1
reach
"As HOIP associated OTULIN was not recruited to SCs, we next studied whether OTULIN deficiency may increase levels of linear ubiquitin found in the cytosol."
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signor
"Here we provide data suggesting that two of the four mammalian ubiquitin precursors, UBA52 and UBA80, are processed mostly post-translationally whereas the other two, UBB and UBC, probably undergo a combination of co- and post-translational processing. Using an unbiased biochemical approach we found that UCHL3, USP9X, USP7, USP5 and Otulin/Gumby/FAM105b are by far the most active DUBs acting on these precursors."
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