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BAP1 ubiquitinates SLC7A11. 4 / 4
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"A recent study reported that BAP1 inhibits cystine uptake and makes cells more susceptible to ferroptosis by deubiquitinating H2Aub on SLC7A11."
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"Specifically, our study suggests a model in which the tumor suppressor BAP1 normally functions to repress the expression of SLC7A11 at least partly by deubiquitinating H2Aub on SLC7A11, thereby inhibiting cystine uptake into cells and rendering them more sensitive to ferroptosis."
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"18, NO. 8, 773-783 https://doi.org/10.1080/15384101.2019.1597506EXTRA VIEWRegulation of H2A ubiquitination and SLC7A11 expression by BAP1 and PRC1Yilei Zhang a, Pranavi Koppula a, b, and Boyi Gan a, baDepartment of Experimental Radiation Oncology, the University of Texas MD Anderson Cancer Center, Houston, TX, USA; bDepartment of Experimental Radiation Oncology, The University of Texas MD Anderson UTHealth Graduate School of Biomedical Sciences, Houston, TX, USAABSTRACTSLC7A11 (or xCT) imports extracellular cystine into cells to promote glutathione synthesis, thus inhibiting ferroptosis."
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"Cell CycleISSN : 1538-4101 (Print) 1551-4005 (Online) Journal homepage : https://www.tandfonline.com/loi/kccy20Regulation of H2A ubiquitination and SLC7A11 expression by BAP1 and PRC1Yilei Zhang, Pranavi Koppula & Boyi GanTo cite this article : Yilei Zhang, Pranavi Koppula & Boyi Gan (2019) Regulation of H2A ubiquitination and SLC7A11 expression by BAP1 and PRC1, Cell Cycle, 18:8, 773-783, DOI : 10.1080/15384101.2019.1597506 To link to this article : https://doi.org/10.1080/15384101.2019.1597506View supplementary material Accepted author version posted online : 23 Mar 2019."
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