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USP15 deubiquitinates RI. 8 / 8
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"Eichhorn et al. have reported that USP15 is highly expressed in glioma and deubiquitinates and stabilizes TβRI, leading to an enhanced TGFβ1/Smad signaling."
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"Similarly, Inui et al. revealed that USP15 could directly bind to R-Smads and deubiquitinate TβRI, thereby promoting its stability and up-regulating the activity of TGFβ1/Smad signaling."
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"USP15 is an important member of the deubiquitinating enzyme family; we further verified whether USP15 could deubiquitinate TβRI in hypertrophic scar–derived fibroblasts."
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"The ubiquitination assay showed that USP15 knockdown significantly increased the TβRI ubiquitination levels in hypertrophic scar–derived fibroblasts, whereas USP15 overexpression significantly reduced the TβRI ubiquitination levels in hypertrophic scar–derived fibroblasts."
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"(See Figure, Supplemental Digital Content 6, which shows a schematic depiction of USP15 enhancing TGFβ1/Smad signaling by deubiquitinating TβRI in hypertrophic scar, http://links.lww.com/PRS/E649."
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"Co-immunoprecipitation and ubiquitination assays showed that USP15 knockdown significantly increased the TβRI ubiquitination levels in hypertrophic scar–derived fibroblasts, whereas USP15 overexpression significantly reduced the TβRI ubiquitination levels in hypertrophic scar–derived fibroblasts."
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"These data demonstrated that USP15 increased the activity of TGFβ1/Smad signaling by deubiquitinating TβRI in hypertrophic scar–derived fibroblasts."
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"Several of these, specifically ubiquitin specific protease (USP)4, USP11, USP15, and ubiquitin C-terminal hydrolase (UCH)37, were shown to deubiquitylate TβRI, either through direct association with t[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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