IndraLab

Statements

OTUD5 activates ATM. 6 / 6
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"OTUD5 promotes ATM-dependent DDR signaling."
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"As independently, UBR5 was found to inhibit the interaction between ATM and ATMIN, a negative regulator of canonical DSB-induced ATM activation , we hypothesized that OTUD5 may promote ATM-dependent DDR signaling via stabilization of UBR5."
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"OTUD5 promotes ATM-dependent DDR activation by regulating the UBR5-ATMIN axis."
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"Indeed, we found OTUD5 to promote ATM-dependent DDR signaling in a manner that is epistatic with UBR5, dependent on its catalytic activity and involving ATMIN, supporting that OTUD5 acts via UBR5.Early biochemical studies performed on OTUD5 suggested that phosphorylation at residue Ser-177 is vital for its DUB activity in vitro ."
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"These previously established links prompted us to hypothesize that OTUD5 promotes ATM-dependent DDR and telomeric DNA repair in a UBR5 and ATMIN-dependent manner."
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"If OTUD5 indeed promotes ATM-dependent DDR and telomeric DNA repair through the UBR5-ATMIN axis, ablation of ATMIN is expected to reverse the DDR defects exhibited by OTUD5-depleted cells."
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