IndraLab
Statements
reach
"Activation of PKC-alpha inhibited beta-catenin response transcription by down-regulation of intracellular beta-catenin and induced phosphorylation of the N-terminal serine and threonine residues (Ser33/Ser37/Thr41) of beta-catenin, marking it for proteasomal degradation, in colon cancer cells."
reach
"In the absence of Wnt ligand, Axin contributes to the formation of beta-catenin destruction complex, which leads to phosphorylation of beta-catenin on serine and threonine residues near its N-terminus providing beta-catenin a target for ubiquitination and rendering it to ubiquitin dependent proteasome mediated degradation [XREF_BIBR, XREF_BIBR, XREF_BIBR]."