IndraLab

Statements

USP35 activates 3,5-dihydroxy-3-methylpentanoic acid. 5 / 5
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"In this study, we highlighted the SREBP2-dependent MVA crosstalk is activated by USP35/BRFP1 axis to drive tumor progression."
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"We would design other assays in the future to confirm whether USP35-mediated MVA metabolism could influence the progression of Castration-Resistant Prostate Cancer (CRPC)."
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"Taken together, these data implicated that USP35/BRPF1 axis could modulate MVA crosstalk in PRAD in a SREBP2-dependent manner."
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"Meanwhile, USP35 could activate MVA signature and this effect could be completely abolished by BRPF1 KD (Fig. 6B)."
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"Thus, USP35/BRPF1 axis modulated the MVA crosstalk via induction of SREBP2."
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