IndraLab

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USP14 activates NFkappaB. 3 / 4
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"Importantly, we found that depletion of USP14 resulted in downregulation of TNF‐α, IL‐6, and IL‐1β mRNA expression in HTR8/Svneo and B6Tert‐1 (Figure 4B–D), suggesting that USP14 regulates TNF‐α, IL‐6, and IL‐1β expression through activation of NF‐κB activity.3.5 Inhibition of USP14 suppressed H/R-induced NF-kappaB and MAPK activation."
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"Conversely, USP14 KD THP-1 cells clearly enhanced NF-kappaB activation and the production of proinflammatory cytokines such as TNF-alpha, IL-6, and IL-1beta."
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"Based on these results, USP14 can induce the activation of NF-kappaB and regulate the up-regulation of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and interleukin-18 (IL-18) expression by activating the NF-kappaB signal pathway."
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