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USP15 binds E3_Ub_ligase. 2 / 2

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"In the nucleus, Usp15 indirectly associates with the ubH2B E3 ligase, RNF20/RNF40, and directly associates with a component of the splicing machinery, SART3 (also known as TIP110 or p110)."

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"For example, glioblastomas can overexpress USP15, which binds to the SMAD7-SMAD specific E3 ubiquitin protein ligase 2 (SMURF2) complex to deubiquitinate and stabilize the type I TGF-β receptor (TβR-I), enhancing TGF-β signaling ."

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USP15 binds E3_Ub_ligase. 2 / 2

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