IndraLab

Statements

Martentoxin activates KCNMA1. 4 / 4
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"Thus, the results shown here provide the novel evidence that martentoxin could increase the two Ca (2+)-hypersensitive BK channel subtypes activities in a new manner and indicate that beta subunit of these BK channels plays a vital role in this enhancement by martentoxin."
21445248
reach
"In the presence of cytoplasmic Ca (2+), martentoxin could enhance the activities of both gBK and BK channel (alpha+ beta1) subtypes in dose dependent manner with EC (50) of 46.7 nM and 495 nM respectively, while not shift the steady-state activation of these channels."
21445248
reach
"Martentoxin, a 37 residues toxin from Buthus martensi Karsch (BmK), can block BK channel in adrenal medulla chromaffin cells and modulate the activities of neuronal BK channel subtype (alpha+ beta4) with Ca 2+ -dependent manner XREF_BIBR, XREF_BIBR."
21445248
reach
"Martentoxin can significantly increase the activity of the BK channel (α+β1) subtype with an EC of 495 nM [48]."
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