IndraLab

Statements

USP9X decreases the amount of TP53. 2 / 2
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"USP9X knockdown eliminated the decreased p53 expression caused by WP1130 in the presence of cisplatin."
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"Among the compounds targeting USP9X, a non specific inhibitor of USP9X, named (EOAI3402143) G9, belonging to the USP9X-second generation inhibitors, has been shown to destabilize the pro survival protein MCL1 and increased p53 levels, promoting apoptosis in a dose dependent manner and reducing tumor growth of human myeloma xenograft [XREF_BIBR]."
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