IndraLab

Statements


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"Overall, the data in this study indicate that Cacna1c modulates ML-DA dependent behavior and DA terminal dynamics, potentially through altered DA reuptake by VTA neurons."

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"In addition to functioning downstream of dopamine D1 receptors, cacna1c also mediates the effects of beta-adrenergic receptor activation [45]."

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"Reduced levels of Cacna1c attenuate mesolimbic dopamine system function."

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"Using rodent models of reduced Cacna1c function both globally and in specific brain regions, we show that Cacna1c modulates DA dependent stimulant induced locomotor activity and sensitization."

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"Further studies confirmed that Cacna1c mRNA and protein are downregulated by miR-153 mimics and upregulated by miR-153 inhibitors in insulin secreting freshly isolated mouse islets, in the insulin secreting mouse cell line MIN6 and in the dopamine secreting cell line PC12."

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"Therefore we show that Cacna1c modulates DA reuptake and that its function in the VTA is necessary for the development of stimulant induced sensitization."

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"Here, we further characterized the role of that decreased Cacna1c function on ML-DA system mediated behaviors and hypothesized that stimulant induced DA release and/or reuptake would be modulated by Cacna1c levels."