IndraLab

Statements

KCNA3 binds SHPK. 8 / 8
| 5 3
reach
"The discovery that ShK toxin from sea anemone binds to K V 1.3 with a picomolar affinity has focused efforts to develop a therapeutic agent from ShK ( Chi et al., 2012 )."
28778835
reach
"Although these peptides have quite different dynamics, the dyad in both adopts a similar configuration upon binding, revealing a conformational selection upon binding to K V 1.3 in the case of ShK."
37143234
reach
"It should be noted however that in the case of a ShK toxin derivative binding to the Kv1.3 channel, Tyagi et al. (2022) observed that binding occurs to inactivated channels."
37398110
reach
"The C4-symmetric reconstruction did not yield an interpretable map of the toxin, but clear ion densities in IS2, IS3 and IS4 were visible.Selvakumar et al. (2022) also obtained a structure of ShK bound to Kv1.3, but in this case the ShK toxin was fused to a Fab fragment; this yielded an asymmetric ligand large enough to allow C1 reconstruction from the cryo-EM images."
37398110
sparser
"Therefore, it remains to be determined whether multiple binding modes would be required to describe the binding of ShK to Kv1.3."
26633507
sparser
"Contrasting the binding modes of ShK and ShK-K-amide ( xref ), it is seen that Arg1 is already involved in binding of ShK to Kv1.3 so the mutation leads to some rearrangement among the contact pairs but their number and quality as measured by the contact distances are preserved."
23063513
reach
"18 Here, we report a novel, continuous binding epitope mimetic of ShK.Information about the binding interactions between Kv1.3 and ShK has been provided by two studies."
15935664
sparser
"Models of D-allo-ShK bound to Kv1.3 show that it can block the pore as effectively as ShK but makes different interactions with the vestibule, some of which are less favorable than for native ShK."
17984097