IndraLab

Statements

SHPK binds KCNA3. 4 / 4
| 1 3
sparser
"Contrasting the binding modes of ShK and ShK-K-amide ( xref ), it is seen that Arg1 is already involved in binding of ShK to Kv1.3 so the mutation leads to some rearrangement among the contact pairs but their number and quality as measured by the contact distances are preserved."
23063513
sparser
"Therefore, it remains to be determined whether multiple binding modes would be required to describe the binding of ShK to Kv1.3."
26633507
reach
"Although these peptides have quite different dynamics, the dyad in both adopts a similar configuration upon binding, revealing a conformational selection upon binding to K V 1.3 in the case of ShK."
37143234
sparser
"Models of D-allo-ShK bound to Kv1.3 show that it can block the pore as effectively as ShK but makes different interactions with the vestibule, some of which are less favorable than for native ShK."
17984097