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BAP1 activates Deubiquitinase. 3 / 3
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"We confirmed that re-expression of BAP1 WT, but not its C91A mutant, in UMRC6 cells decreased SLC7A11 expression (XREF_FIG), suggesting that BAP1 mediated repression of SLC7A11 expression requires BAP1 's DUB activity."
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"In addition to TFs, SLC7A11 transcription is also repressed by BRCA1-associated protein 1 (BAP1) – a major component of a deubiquitinase (DUB) complex which catalyzes deubiquitination of histone 2 A (H2A) associated with the SLC7A11 promoter.96 Not surprisingly, BAP1 promotes ferroptosis in a DUB-dependent manner."
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"Incubation of BAP1 with increasing concentrations of TG2-179-1 reduced the emission of fluorescence from Ub-AMC in a dose-dependent manner (Fig. 5C), indicating that TG2-179-1 inhibited the DUB activity of BAP1."
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