IndraLab

Statements

Ezogabine activates KCNQ1. 7 / 7
| 1 5 1
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"Retigabine, a small molecule that activates KCNQ2-5 channels, but not the KCNQ1 channel, was approved by the US Food and Drug Administration in 2011."
33846771
reach
"KCNQ1 is not activated by retigabine because KCNQ1 lacks the S5 Trp."
32655402
reach
"The M-type current was activated by 1) 10 muM retigabine, an opener of all KCNQ channels except KCNQ1, 2) 10 muM zinc pyrithione, which augments all KCNQ channels except KCNQ3, and 3) 50 muM N-ethylmaleimide, which activates KCNQ2, KCNQ4, and KCNQ5, but not KCNQ1 or KCNQ3, channels."
22135213
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"Retigabine, for example, activates KCNQ2-5 but not KCNQ1 (because it lacks the S5 Trp); conversely, aloperine is relatively KCNQ5 specific."
32655402
eidos
"KCNQ1 is not activated by retigabine because KCNQ1 lacks the S5 Trp ( Schroder et al ., 2001 ) ."
32655402
sparser
"KCNQ1 is not activated by retigabine because KCNQ1 lacks the S5 Trp ( xref )."
32655402
reach
"In contrast, retigabine did not enhance cardiac KCNQ1 currents."
11466425