IndraLab

Statements

Resveratrol inhibits STAT1. 9 / 11
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"In addition, resveratrol also inhibited the activation of signal transducer and activator of transcription (STAT1 and STAT3) and prevented the proinflammatory effect of Aβ and Aβ-triggered microglial activation [140]."
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"Resveratrol inhibits IFN-γ-induced macrophage STAT1 transcription activity and IFN-γ-induced Tyr701 or Ser727 p-STAT1."
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"Furthermore, when used at 50 μM concentration, both resveratrol and quercetin abrogated basal IRF1 and P-STAT1 and prevented cetuximab- or gefitinib-driven enhancement of both these proteins (Figure 2C,D)."
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"The JAK/STAT modulation potential of resveratrol has been seen in IFN-γ induced RAW 264.7 cells, wherein treatment with resveratrol inhibited JAK2 and STAT1."
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"Although compound 8 has different structural features than previously studied JAK2 inhibitors, such as AG490, SD-1029, MK-0457, and AT9283 [48,49] , the possibility that this compound is a JAK2 inhibi[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In this respect, resveratrol decreased STAT1 activation (an important transcription factor for IFN-γ-induced genes) and hindered JAK-2 activation (Chung et al., 2011)."
| PMC
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"In stark opposition, resveratrol blocked the AKT, c-Raf, NF-κB, and STAT1 pathways, thereby suppressing the manifestation of inflammatory elements such as TNF-α, IL-6β, IL-3, and TGF-β."
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eidos
"In this respect , resveratrol decreased STAT1 activation ( an important transcription factor for IFN-gamma-induced genes ) and hindered JAK-2 activation ( Chung et al ., 2011 ) ."
| PMC
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"Treatment of resveratrol dose-dependently inhibited IFN-γ-induced transcriptional activity of STAT-1 with an IC 50 value of 29 μM ( Fig. 3 A)."
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