IndraLab

"C unbound plasma concentration E maximal hERG mediated QT prolongation f fraction unbound hERGhuman ether-a-go-go-related gene I repolarizing potassium current mediated by the delayed rectifier potassium channel K receptor affinity Lligand LRligand and receptor complex (receptor occupancy) LR ligand and receptor complex concentration leading to half-maximal system effect NONMEMnonlinear mixed effect modeling QTcQT interval corrected for heart rate and circadian variation DeltaQTcdrug induced QTc prolongation R receptor density gammaslope (sigmodicity) of transducer function DeltaOFVdifference in NONMEM objective function value tautransducer ratio f relative transducer ratio Introduction."