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"Similarly, berberine inhibited a cAMP stimulated and chromanol 293B sensitive whole-cell conductance, suggesting berberine inhibits KCNQ1 channels."

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"In HEK-293 cells, the IC50 for berberine was 3.1 +/- 0.5 microM on hERG compared with 11 +/- 4% decreases on KCNQ1 and KCNE1 channels by 100 microM berberine."