IndraLab

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USP9X inhibits apoptotic process. 38 / 41
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"Although both Usp9X and Mcl-1 knockdown elicited some features of apoptosis, broad spectrum caspase inhibition was ineffective in preventing knockdown-induced MPNST cell death suggesting that caspase-independent death pathways were also activated."
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"Inhibition of USP9X by WP1130 downregulates MCL1 protein , inducing apoptosis in CML cell lines [ 103 ] ."
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"In contrast, USP9x knockdown slightly increased apoptosis in IR resistant A172 cells and significantly in Ln229 cells and reduced clonogenic survival after irradiation only on these two cell lines."
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"Considering our observations with respect to Bcl-2 family members and IAPs, Usp9X appears to block death-receptor-mediated apoptosis most likely at the level of initiator- as well as effector caspases, involving a combination of factors."
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"The involvement of apoptotic cell death is in agreement with other recent studies that have shown that Usp9X loss-of function activates or enhances apoptosis [XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR - XREF_BIBR]."
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"Together, our results indicate that radiation induced activation of USP9x inhibits Mcl-1 degradation and apoptosis resulting in increased radioresistance."
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"Inhibition of USP9X Downregulates JAK2-V617F and Induces Apoptosis Synergistically with BH3 Mimetics Preferentially in Ruxolitinib-Persistent JAK2-V617F-Positive Leukemic Cells."
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"revealed that loss of Usp9x increased apoptosis in the hippocampus and medial neocortex at E18.5 and P0 (Usp9x +/Y = 1.1 +/-1.1 cells (n = 9) versus Usp9x -/Y 5.9 +/-5.1 cells, n = 10; p = 0.013)."
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"Conversely, knockdown of lncRNA FAF could promote apoptosis in ischemia-hypoxia cardiomyocytes."
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"We speculated that inhibiting USP9X might induce apoptosis in FaDu cells by downregulating Mcl-1 and upregulating Bax protein expression."
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"Both knockdown and chemical inhibition of USP9X have been shown to efficiently promote cancer cell apoptosis."
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"Deubiquitinase USP9X promotes cell migration, invasion and inhibits apoptosis of human pancreatic cancer."
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"Downregulation of SOX2 by inhibition of Usp9X induces apoptosis in melanoma."
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"In brief, USP9X promoted the migration and invasion of PANC-1 cells probably by provoking epithelial-mesenchymal transition, and also inhibited apoptosis."
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"As inhibition of USP9X resulted in caspase 3 and caspase 8 activation and increased the rates of apoptosis, USP9X might promote cell survival by inhibiting apoptosis in glioma cells."
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"Furthermore, we demonstrated that knockdown of USP24 but not USP9X could significantly induce growth inhibition and apoptosis of T-ALL cells."
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"Usp9X knockdown induces apoptosis, caspase activation and recapitulates effects of CP-d and n-ATF 5-S1."
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"Inhibition of USP9X induces apoptosis in FLT3-ITD-positive AML cells cooperatively by inhibiting the mutant kinase through aggresomal translocation and inducing oxidative stress."
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"FAM129A inhibited apoptosis and promoted migration and proliferation in human cancers."
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"We proved that USP9X overexpression promoted proliferation and cell cycle and suppressed cell apoptosis in MCL cells."
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"Furthermore, ectopic expression of USP9X prevented c-FLIP downregulation and apoptosis upon combined treatment."
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"Although USP9x knockdown reduced Mcl-1 levels and increased apoptosis in A172 cells, USP9x regulated radiosensitivity independently of Mcl-1 in Ln229 cells."
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"We investigated the role of USP9X in B-ALL and found that USP9X knockdown significantly reduced leukemic cell growth and increased spontaneous apoptosis, thereby improving survival in immunodeficient mice."
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"Recently, it was reported that USP9X inhibition promotes cell apoptosis in FLT3-ITD AML cells."
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"Inhibition of the deubiquitinase USP9x induces pre-B cell homeobox 1 (PBX1) degradation and thereby stimulates prostate cancer cell apoptosis."
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"To determine if Usp9X inhibition induced apoptosis of MPNST cells, we inhibited Usp9X pharmacologically with WP1130 and silenced it by siRNA, as well, in ST88-14 and T265-2c cell lines and examined various biochemical indicators of apoptosis."
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"These results suggest that stabilization of acetylated MCL1 is largely dependent on USP9X and that blockade of USP9X enzymatic activity efficiently induces apoptosis."
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"Overexpressing LncRNA FAF can inhibit cardiomyocyte apoptosis induced via ischemia and hypoxia."
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"Since suppression of Usp9X significantly enhances apoptosis induced by ABT263, we determined the effects of ABT263 on Usp9X and Bag3 protein levels."
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"Furthermore, targeting USP9x in Pbx1 expressing PC cells leads to apoptosis (Liu et al., 2019)."
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"USP9X inhibition promotes radiation induced apoptosis in non small cell lung cancer cells expressing mid-to-high MCL1."
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"Here we show that inhibition of the deubiquitinase USP9X by its inhibitor WP1130 or EOAI3402143 (G9) induces apoptosis preferentially in cells transformed by these mutant kinases, including FLT3-ITD-positive AML cell line MV4-11 and primary AML cells."
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"Knockdown of USP9X inhibited cell proliferation and cell cycle progression and increased apoptosis."
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"A novel long noncoding RNA FAF inhibits apoptosis via upregulating FGF9 through PI3K and AKT signaling pathway in ischemia-hypoxia cardiomyocytes."
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"ShRNA mediated Usp9x knockdown suppresses 3D growth in PANC1 cells and induces apoptosis in MIAPACA2 cells."
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"Usp9x knockdown, as well as inhibition with DUB inhibitor, G9, blocked SOX2 expression, suppressed in vitro colony growth, and induced apoptosis of BRAF-mutant melanoma cells."
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"Furthermore, the ubiquitin-proteasome system contains an additional deubiquitinase called ubiquitin specific peptidase 9, X-linked (USP9X) that removes poly-ubiquitin chains leading to stabilize Mcl-1 and prevent apoptosis (Schwickart et al., 2010)."
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"Overexpression of FAF could significantly inhibit cardiomyocytes apoptosis induced by ischemia and hypoxia."
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