IndraLab

Statements

Cholane activates KCNMA1. 3 / 3
| 3
reach
"Modifications at C25 resulting in introduction of partial positive charge and/or additional volume with either positive or negative charges (compounds 13, 16, 18, 21, XREF_TABLE), however, totally ablated cholane induced BK channel activation (XREF_FIG)."
22945504
reach
"We found that shortening the LCA lateral chain (compound 3) practically abolished cholane induced BK channel activation (XREF_FIG)."
22945504
reach
"Slo1 channels, for example, are modulated by cholane steroids only in the presence of ß1-accessory subunits, which harbour three unique amino acids that are essential for steroid binding (Bukiya et al., 2011), whereas cortisone dissociates K channels from the Shaker family from their accessory β subunits, relieving the channel from N-type inactivation (Pan et al., 2008)."
39310227