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"We found that shortening the LCA lateral chain (compound 3) practically abolished cholane induced BK channel activation (XREF_FIG)."

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"Modifications at C25 resulting in introduction of partial positive charge and/or additional volume with either positive or negative charges (compounds 13, 16, 18, 21, XREF_TABLE), however, totally ablated cholane induced BK channel activation (XREF_FIG)."