IndraLab

Statements

Loperamide inhibits KCNH2. 5 / 5
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"Characterization of loperamide mediated block of hERG channels at physiological temperature and its proarrhythmia propensity."
28830713
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"The 50% inhibitory concentration for loperamide inhibition of hERG ionic tail currents was approximately 40 nmol/l."
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"Loperamide can inhibit hERG voltage-gated potassium (K + ) channels (Kv11.1), leading to the prolongation of repolarization, QTc interval prolongation, and increased risk of torsades de pointes."
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"At supra-therapeutic blood levels, loperamide can block cardiac HERG K channels leading to potentially fatal arrhythmias (Eggleston et al., 2016; Kang et al., 2016; Vaughn et al., 2016)."
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"Loperamide suppressed hERG current in a use- and voltage dependent but frequency independent manner, with a half-maximal inhibitory concentration < 90nM."
28830713