IndraLab

Statements

HCN1 activates Ile-His. 7 / 7
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"Deletion of HCN1 or acute pharmacological blockade of Ih decreases the fraction of neurons capable of generating persistent firing."
23966682
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"This difference is consistent with the higher levels of expression of the HCN1 subunit, which underlies Ih, in CA1 neurons compared to CA2 or CA3 neurons."
20510860
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"We also demonstrate via immunohistochemistry, single channel conductance, and analysis of kinetic data of whole cell currents, that Ih in salamander rods and cones is mediated by the HCN1 isoform."
19420251
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"In many cortical neurons, HCN1 channels are the major contributors to Ih, the hyperpolarization activated current, which regulates the intrinsic properties of neurons and shapes their integration of synaptic inputs, paces rhythmic activity, and regulates synaptic plasticity."
23966682
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"Nitric oxide selectively suppresses IH currents mediated by HCN1 containing channels."
25605440
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"Auditory brainstem responses of Hcn1 deficient mice showed longer latencies, suggesting that HCN1 mediated Ih is critical for synchronized spike timing in SGNs."
23980193
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"Ih in salamander rods and cones is mediated by HCN1 channels."
19420251