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USP37 inhibits SIVmac239 WT. 2 / 2
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"The results showed that overexpressing USP37 WT and the catalytic center USP37 (USP37-341-979) could effectively inhibit the production of SIVmac239 WT but has no significant effect on the production of SIVmac239 △Vpx (Fig. 8A and B)."

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"Conversely, USP37-knockdown increased the production of SIVmac239 WT, but it had no significant effect on the production of SIVmac239 △Vpx (Fig. 8C and D), indicating that USP37 suppresses the replication of SIVmac239 WT through inhibiting the Vpx-mediated degradation of SAMHD1."