IndraLab

Statements

Pyraclofos inhibits KCNQ1. 3 / 3
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"The voltage dependent block of KCNQ1 current produced by external Ba 2+ was significantly attenuated in 50 mM [K +] 0, as measured in steady-state experiments."
15226366
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"Channels Gene Protein Mechanism Phenotype Voltage gated Potassium HERG Cardiac delayed rectifier Dominant negative loss of function Episodic cardiac arrhythmias (LOT) (h (r) with reduced repolarizing [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
8791523
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"Voltage dependent inactivation of the human K+ channel KvLQT1 is eliminated by association with minimal K+ channel (minK) subunits."
9625865