IndraLab

Statements

USP15 inhibits Parkinson Disease. 5 / 5
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"USP15 knockdown rescues the mitophagy defect of PARK2 mutant PD patient fibroblasts As demonstrated above in HeLa cells ( Fig. 2A) , USP15 knockdown does not enhance mitophagy in the complete absence of Parkin."
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"The deubiquitinase USP15 antagonizes Parkin-mediated mitochondrial ubiquitination and mitophagy.Loss-of-function mutations in PARK2, the gene encoding the E3 ubiquitin ligase Parkin, are the most frequent cause of recessive Parkinson's disease (PD)."
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"The deubiquitinase USP15 antagonizes Parkin-mediated mitochondrial ubiquitination and mitophagy.Loss-of-function mutations in PARK2, the gene encoding the E3 ubiquitin ligase Parkin, are the most frequent cause of recessive Parkinson's disease (PD)."
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": Knockdown of USP15 rescues the mitophagy defect of PARK2 mutant PD patient fibroblasts."
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"USP15 knockdown rescues the mitophagy defect of PARK2 mutant PD patient fibroblasts."
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