IndraLab

Statements

BAP1 binds N1ICD. 6 / 6
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"In a more stringent assay, the interaction between N1ICD and endogenous BAP1 was validated by FLAG-bound IP in HeLa N1ICD-FLAG cells ( xref )."
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"Parallelly, protein levels of activated NOTCH1 was found to be highly expressed in cortical NPCs ( xref ), and BAP1 associates with endogenous activated N1ICD in cortical NPCs ( xref )."
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"Interestingly, we found that the RAM–ANK and PEST domains of N1ICD, regions required for NUMB association, mediate N1ICD interaction with BAP1 as well ( xref ), and BAP1 regulates N1ICD stability through the PEST domain ( xref )."
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"Moreover, the presence of full-length NUMB, but not the AB-deleted NUMB, significantly enhances the interaction between BAP1 and N1ICD."
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"Finally, NUMB overexpression enhanced the interaction between BAP1 and N1ICD ( xref ), but co-expression of non-N1ICD-bound NUMB-∆2–15 could not promote BAP1–N1ICD association, thus failing to boost stabilization of N1ICD ( xref )."
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"Next, we asked whether BAP1 is associated with N1ICD."
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