IndraLab

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KCNQ1 binds F57Bpa. 2 / 2
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"To determine if F57Bpa directly interacts with KCNQ1, a 300 ms flash of UV light (365 nm) was applied while holding at -90 mV followed by a 4s activation step (+60 mV) and repeated with each successive sweep (XREF_FIG)."
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"Since F57Bpa interacts with KCNQ1 in the channel 's closed state, we used this observation to test whether an independently expressed F57Bpa KCNE1 beta-subunit could enter an open cleft in EQQQQ or EQQ and crosslink with the channel."
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