IndraLab

Statements

HCN4 activates mESC-CMs. 6 / 6
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"Furthermore, HCN4 overexpressing mESC-CMs (HCN4 and EGFP mESC-CMs) showed a significantly larger I f current than did non overexpressing mESC-CMs (EGFP mESC-CMs) (XREF_FIG)."
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"The beating rate of hiPSC-CMs co-cultured with aggregates of HCN4 overexpressing mESC-CMs was significantly higher than that of non treated hiPSC-CMs and that of hiPSC-CMs co-cultured with aggregates of non overexpressing mESC-CMs."
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"HCN4 overexpressing mESC-CMs showed significantly more rapid beating than did non overexpressing mESC-CMs (Control mESC-CMs, 43.1 +/- 4.8 beats and min; HCN4 and EGFP mESC-CMs, 87.4 +/- 11.9 beats and min; EGFP mESC-CMs, 44.3 +/- 11.9 beats and min, n = 8 in each group, P < 0.0001) (XREF_FIG)."
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"HCN4 overexpressing mESC-CMs showed significantly larger I f currents and more rapid spontaneous beating than did non overexpressing mESC-CMs."
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"HCN4 overexpressing mESC-CMs (HCN4 and EGFP mESC-CMs) expressed a 3-times higher level of Hcn4 than did non overexpressing mESC-CMs (EGFP mESC-CMs) (XREF_FIG)."
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"(1) HCN4 overexpressing mESC-CMs expresses high levels of Hcn4 and Cacna1h genes and a low level of the Kcnj2 gene."
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