IndraLab

Statements

USP4 activates cell migration. 8 / 8
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"USP4 has also been shown to target TRAF2 and TRAF6 inhibiting nuclear factor-kappaB (NF-kB) signalling and antagonizing lung cancer cell migration XREF_BIBR XREF_BIBR XREF_BIBR, suggesting a context dependent role in cancer."
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"Collectively, these data demonstrated that USP4 promotes melanoma cell migration and invasion by promoting EMT."
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"Using gene interference, we demonstrated that USP4 knockdown significantly inhibited HCC cell migration and invasion in vitro, and USP4 overexpression had the opposite results."
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"Transwell assays showed that USP4 knockdown inhibited cell migration and invasion in MHCC97H and LM3 cells."
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"In addition, USP4 depletion inhibits breast cancer cell migration, which is induced by AKT [13]."
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"Moreover, USP4 upregulation promoted Huh7 and PLC/PRF/5 cell migration and invasion ability (P < 0.01 for all)."
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"The migration and invasion assays showed that USP4 promotes human breast cancer cell migration and invasion by USP4 overexpression, and knockdown of USP4 by siRNA inhibits human breast cancer cell migration and invasion."
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"Subsequently , Cao et al. further confirmed that USP4 can promote cell migration and invasion through relaxin / TGF-beta1 / smad2 / matrix metalloprotein-9 signaling pathway [ 92 ] ."
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