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BAP1 activates HSF1. 3 / 3
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"These findings imply that the absence of BAP1 can augment cellular sensitivity to specific therapeutic interventions, thereby furnishing a theoretical rationale for therapies aimed at BAP1-associated cancers.Additionally, our prior research has unveiled that BAP1 can modulate the activity of HSF1 through a non-enzymatic mechanism, ultimately impacting the responsiveness to immune checkpoint inhibitors33."
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"Given that BAP1 modulates the transcriptional activity of HSF1 without impacting its expression, we sought to investigate whether BAP1 exerts its influence on HSF1 activity through post-transcriptional mechanisms."
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"However, the luciferase report gene assay indicated that the knock-out of BAP1 notably upregulates the transcriptional activity of HSF1 (Fig. 2F)."
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