IndraLab

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USP7 increases the amount of CD274. 14 / 14
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"On the contrary, another study found that USP7 inhibition elevated the PD-L1 expression in lung cancer cells [57], suggesting that the regulation of PD-L1 expression by USP7 is multifaceted and may be context-dependent.Different subsets of DCs are specialized for eliciting specific elements of the immune response."
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"Western blot showed that CPP-A11 obviously inhibited USP7-upregulated endogenous PD-L1 levels in the three types of human cancer cells (figure 2I) and also inhibited exogenous USP7-upregulated exogenous PD-L1 levels in HEK293 cells (figure 2J)."
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"Silencing USP7 decreases PD-L1 expression on cell surfaces, and augments the T cell-mediated killing of cancer cells (19)."
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"USP7 Enables Immune Escape of Glioma Cells by Regulating PD-L1 Expression."
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"3.2 Inhibition of USP7 decreased PD-L1 expression in GC cells."
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"Recent experiments in mouse models of lung cancer have shown that (89) targeting USP7 with USP7 inhibitor P5091 upregulates the expression of PD-L1 protein in Lewis tumor cells and blocks PD-1, leading to an effective anti-tumor response in lung cancer."
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"Silencing USP7 leads to decreased PD-L1 expression and increased T-cell-mediated cancer cell destruction [91]."
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"Moreover, USP7 significantly upregulated exogenous PD-L1 levels and decreased its polyubiquitination levels in the HEK293 cells cotransfected with USP7 and PD-L1 expression plasmids (online supplemental figure S5F, G)."
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"Consistently, suppression of USP7 dramatically decreased the protein level of TGF-β, VEGF, IL-6, COX-2, cyclin D1 and PD-L1, which was rescued by combined inhibition of TIMP2 ( Fig. 5 E)."
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"USP7 inhibition in tolerogenic Stat5b-CA.DCs increased their maturation phenotype while reducing PD-L1 and PDL-2 expression and enhancing the production of proinflammatory cytokines TNF-α, IL-1β, and IL-6."
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"Inhibition of USP7 may inhibit the proliferation of gastric cancer cells by halting the cell cycle during the G2-M phase, maintaining p53 expression, and downregulating PD-L1 expression."
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"Knockdown of USP7 by siRNAs significantly decreased PD-L1 protein levels (online supplemental figure S5D) and increased PD-L1 ubiquitination levels in the three types of human cancer cells (online supplemental figure S5E)."
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"Moreover, USP7 can promote the amount of PD-L1 in a dose dependent manner (XREF_FIG D)."
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"In gastric tumors, USP7 suppression diminishes PD-L1 levels, increases the susceptibility of GC cells to T-cell-mediated destruction, and enhances the immune response [208]."
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