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Statements

USP47 activates Wnt. 11 / 12
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"In human cells , knockdown of USP47 inhibited Wnt reporter activity , and USP47 acted downstream of the beta-catenin destruction complex ."
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"USP47 also augments Wnt signaling through deubiquitination of beta-catenin in A549 lung and PC3 prostate cancer cells 18."
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"We found that USP47 knockdown inhibited Wnt signaling in HCT116 cells ( Fig. 3D ) ( 18 ) ."
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"In human cells, knockdown of USP47 inhibited Wnt reporter activity, and USP47 acted downstream of the beta-catenin destruction complex."
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"Given that USP47 opposes the activity of XIAP , a positive Wnt regulator , by deubiquitylating its substrate , Gro / TLE , the finding that USP47 promotes Wnt signaling was unexpected ."
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"USP47 also increases Wnt signaling through deubiquitination of β-catenin, an important EMT biomarker, in A549 lung and PC3 prostate cancer cells [ 20 ]."
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"The results indicate that USP47 induces a positive process in Wnt and beta-catenin signaling while increasing the stability of beta-catenin [XREF_BIBR, XREF_BIBR]."
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"We found that USP47 knockdown inhibited Wnt signaling in HCT116 cells (Fig. 3D) (18)."
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"Future studies will focus on whether high amounts of USP47 potentiate Wnt signaling in pancreatic cancers with RNF43 mutations."
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"Given that USP47 opposes the activity of XIAP, a positive Wnt regulator, by deubiquitylating its substrate, Gro/TLE, the finding that USP47 promotes Wnt signaling was unexpected."
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"knockdown of USP47 boosts β-catenin ubiquitination, reduces Wnt signaling, and inhibits the development of cancer cells [26] ."
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