IndraLab

Statements


UCHL1 deubiquitinates EGFR. 5 / 5
| 5

reach
"UCHL1 inhibits EGFR ubiquitination and degradation."

reach
"As noted above, Chen et al. proposed that UCHL1 deubiquitinates and stabilises EGFR, which subsequently represses ER transcription through hyperactivation of MAPK [41] and UCHL1 inhibition using LDN-57444 or knockdown induced ER expression in ER− breast cancer cells."

reach
"UCHL1 deubiquitinates epidermal growth factor receptor, preventing its degradation and resulting in the activation of multiple downstream signaling cascades that positively regulate cardiac hypertrophy."

reach
"In addition, knockdown of UCHL1 increased EGFR polyubiquitination and decreased the EGFR level with or without EGF stimulation."

reach
"In 2020, Chen et al. through various lines of experimental evidence provided a more detailed explanation for this correlation, proposing that UCHL1 deubiquitinates and stabilises Epidermal Growth Factor Receptor (EGFR), which in turn causes suppression of ER transcription [41]."