IndraLab

Statements

UCHL1 deubiquitinates EGFR. 5 / 5
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"UCHL1 inhibits EGFR ubiquitination and degradation."
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"As noted above, Chen et al. proposed that UCHL1 deubiquitinates and stabilises EGFR, which subsequently represses ER transcription through hyperactivation of MAPK [41] and UCHL1 inhibition using LDN-57444 or knockdown induced ER expression in ER− breast cancer cells."
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"UCHL1 deubiquitinates epidermal growth factor receptor, preventing its degradation and resulting in the activation of multiple downstream signaling cascades that positively regulate cardiac hypertrophy."
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"In addition, knockdown of UCHL1 increased EGFR polyubiquitination and decreased the EGFR level with or without EGF stimulation."
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"In 2020, Chen et al. through various lines of experimental evidence provided a more detailed explanation for this correlation, proposing that UCHL1 deubiquitinates and stabilises Epidermal Growth Factor Receptor (EGFR), which in turn causes suppression of ER transcription [41]."
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