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"Similarly, the recently identified DUB OTULIN XREF_BIBR, XREF_BIBR, XREF_BIBR negatively regulates NOD2 mediated signalling by preventing LUBAC autoubiquitination under basal conditions, as well as restricting the accumulation of linear ubiquitin chains on RIP2 and LUBAC upon stimulation (Fig XREF_FIG)."