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ATXN3 inhibits F_actin. 2 / 2
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"Using this experimental system, an ectopic expression of pathogenic SCA3 and SCA1 inhibited the formation of F-actin in the class III and IV da neurones through the Rac-PAK signalling pathway, and affected dendrite maintenance [143]."
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"Previously, we reported that F-actin structures were disrupted by pathogenic SCA3 polyQ proteins leading to dendrite defects."
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