IndraLab

Statements

Anthra[1,9-cd]pyrazol-6(2H)-one inhibits RELA. 3 / 3
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"The subsequent application of JNK (SP600125), NFkappaB (PDTC), and serine protease (TPCK) inhibitors significantly inhibited the proliferation and IL-2 production of SP treated lymphocytes as well as the phosphorylation of JNK and IkappaB, the activation of nuclear NFkappaB p65, and binding of NFkappaB p65 DNA."
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"We found that SP600125 inhibited the translation of NF-kappaB p65 and cell inflammation and apoptosis induced by infection."
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"Twenty micromolar SP600125 and 10 muM SB203580 reduced the lipopolysaccharide caused increase in the NF-kappaB p65 to DNA binding activity in HaCaT cells."
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