IndraLab

Statements

E6 inhibits USP15. 3 / 3
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"The E6 protein inhibits TRIM25 and USP15, which are essential for RIG-I activation via ubiquitination."
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"The human papillomavirus (HPV) E6 oncoprotein antagonizes the activation of DDX58 by targeting TRIM25 and USP15 [100]."
35632621
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"Through in vitro studies, Chiang et al. demonstrated that the HPV16 E6 protein inactivates two upstream activators of RIG-I, TRIM25 and USP15, and blocks the RIG-I-induced IFN response to Sendai virus infection [107]."
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