IndraLab

Statements

Cyclosporin A inhibits NFKB1. 3 / 3
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"Meyer et al. reported that CsA acts as a non competitive inhibitor of the chymotrypsin like activity of the proteasome, enabling it to block Lipopolysaccharide (LPS)-induced IkappaB degradation and p105 processing in vivo [XREF_BIBR]."
27043634
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"CsA neither inhibits the processing of the NF-kappa B1 precursor p105 to p50, nor does it " stabilize " the C-terminal portion of p105, I kappa B gamma, which is degraded during p105 processing to mature p50."
9247567
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"Cyclosporine also inhibits NFKB activity through its action on the 20S proteasome."
33746983