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P38 activates SCN10A. 4 / 4
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"On the one hand, CXCL10 binding to CXCR3 is able to activate p38, which in turn activates Nav1.8 [ xref ]; on the other hand, activated CXCR3 could activate the Akt/ERK and MAPK pathways [ xref , xref ], thereby increasing neuronal excitability."
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"For example, IL-1β signaling causes sensitization of sodium currents in primary afferents through p38-MAPK activation causing a reduction in the voltage dependent block of Nav1.8 and Nav1.9 (Binshtok et al., 2008)."
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"Phosphorylation of Nrf2 in HepG2 cells was enhanced in PN3, which was mediated by PKCdelta, ERK, and p38 MAPK."
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"Whether CXCL13 could modulate the function of sodium channel Nav1.8 by p38 MAPK pathway remains to be investigated.In the present study, we explored the role of CXCL13/CXCR5 in the DRG in inflammatory pain using the well-established complete Freund’s adjuvant (CFA) model."
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