IndraLab

Statements

DNAJA4 inhibits KCNH2. 2 / 2
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"Our observations are thus similar to those described by Walker and colleagues, who reported that DnaJA1, DnaJA2 and DnaJA4 reduced hERG channel maturation, whereas over-expression of Hsc70 alone had no effect on maturation events XREF_BIBR."
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"Rather, DNAJA1, DNAJA2, and DNAJA4 overexpression in HEK-293 and HeLa cells inhibited the hERG maturation and trafficking in an Hsc70-dependent manner (Walker et al., 2010)."
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