IndraLab

Statements

Lipopolysaccharide inhibits JUN. 13 / 13
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"In human THP-1 monocytic cells and human blood monocytes, resveratrol upregulates miR-663 expression [XREF_BIBR, XREF_BIBR]; miR-663 decreases endogenous activator protein-1 (AP-1) activity and impairs lipopolysaccharide (LPS) induced upregulation of AP-1in THP-1 cells, in part, by directly targeting Jun B and Jun D transcripts [XREF_BIBR]; miR-663 is further involved in a resveratrol related pathway through targeting transforming growth factor-beta1 [XREF_BIBR]."
23870168
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"JNK inhibition with SP600125 blocked LPS induced c-Jun activity, which is a direct and specific downstream target of JNK activity."
23034047
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"Our results indicated that 4MR treatment attenuated LPS-induced c-Jun at the mRNA and protein levels, but not for c-Fos, indicating inhibition of the AP-1 pathway, while Pte had no effect on the expression of LPS-induced c-Jun and c-Fos (Figure 6)."
29751609
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"Wogonoside inhibits inflammatory cytokine production in lipopolysaccharide stimulated macrophage by suppressing the activation of the JNK and c-Jun signaling pathway."
32411755
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"ATA not only inhibited nuclear factor-kappaB (NF-kappaB) activation through impairment of the targeting and degradation of IkappaBs but also reduced LPS induced activator protein-1 (AP-1) activation."
12065759
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"In human THP-1 monocytic cells and human blood monocytes, resveratrol upregulates miR-663 expression [XREF_BIBR, XREF_BIBR]; miR-663 decreases endogenous activator protein-1 (AP-1) activity and impairs lipopolysaccharide (LPS) induced upregulation of AP-1in THP-1 cells, in part, by directly targeting Jun B and Jun D transcripts [XREF_BIBR]; miR-663 is further involved in a resveratrol related pathway through targeting transforming growth factor-beta1 [XREF_BIBR]."
23870168
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"By inhibiting phosphorylation and nuclear translocation of Jun, HTMC suppressed LPS induced activator protein-1 (AP-1) activation."
26852953
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"In THP-1 cells, miR-663 decreases endogenous activator protein-1 (AP-1) activity and impairs lipopolysaccharide (LPS) induced upregulation of AP-1 by, in part, by directly targeting the Jun B and Jun D transcripts."
21518431
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"The results obtained by electrophoretic mobility shift assay (EMSA) demonstrated a concentration dependent reduction of the LPS stimulated activation of NF-kappaB and activator protein-1 (AP-1) by lirioresinol B dimethyl ether in in vitro and in vivo models."
31129419
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"In THP-1 cells, miR-663 decreases endogenous activator protein-1 (AP-1) activity and impairs lipopolysaccharide (LPS) induced upregulation of AP-1 by, in part, by directly targeting the Jun B and Jun D transcripts."
21518431
reach
"KB-34, a newly synthesized chalcone derivative, inhibits lipopolysaccharide stimulated nitric oxide production in RAW 264.7 macrophages via heme oxygenase-1 induction and blockade of activator protein-1."
19174156
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"Activated GR inhibited LPS induced activator protein 1 activity, which in turn decreased activating transcription factor 2/c-Jun phosphorylation."
18945810
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"We found that the extracted OECs-Exo could be engulfed by microglia and partially reverse the LPS-induced pro-inflammatory polarization through inhibiting NF-κB and c-Jun signaling pathways in vitro."
35600663