IndraLab

Statements

Momelotinib inhibits TBK1. 3 / 3
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"Momelotinib also inhibits TBK1 [ xref , xref ], which is critical for type I interferon (IFN) production (e.g., IFN-beta) in an autocrine loop and as part of broader antiviral signaling."
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"The multi-targeted kinase inhibitor momelotinib inhibits both JAK1/2 and the TBK1 (and IKKe) kinases."
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"In B cells we observed a shift of altered effectors away from JAK-STAT signaling and differential responses by the inhibitors: pacritinib suppressed IκBα, phospho-ERK, and phospho-CREB levels, while momelotinib inhibited pTBK1."
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