IndraLab

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KCNH1 activates p38. 8 / 8
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"To explore the molecular mechanism underlying the oncogenic role of Eag1 in liposarcoma, we focused on p38 MAPK pathway because Eag1 has been shown to activate p38 MAPK pathway [XREF_BIBR], which is frequently activated in a variety of tumors [XREF_BIBR]."
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"XREF_BIBR Therefore, it is possible that overexpression of Eag induces the activation of p38 MAPK which then promotes the proliferation of osteosarcoma cells because we showed that the inhibition of p38 MAPK and p53 pathway led to reduced MG-63 cell proliferation."
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"Eag has also been shown to activate p38 MAPK and stimulate proliferation of several cell lines in a voltage dependent manner that does not require ion flux."
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"Eag1 Silencing Reduces p38 MAPK Activity in Liposarcoma Cells."
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"Taken together, these data indicate that Eag1 knockdown may inhibit the activation of p38 MAPK which then promotes growth and cell cycle arrest in liposarcoma cells."
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"Taken together, these data indicate that high expression of Eag may induce the activation of p38 MAPK which then promotes the proliferation of MG-63 cells."
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"Therefore, it is possible that Eag1 overexpression induces the activation of p38 MAPK and promotes tumorigenesis."
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"We demonstrated that Eag1 knockdown inhibits the activation of p38 MAPK which then may induce the growth and cell cycle arrest of liposarcoma cells."
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