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USP17L2 deubiquitinates NFE2L2. 8 / 9
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"On the other hand, overexpression of TRIM22 increased NRF2 ubiquitination whereas upregulation of DUB3 decreased NRF2 ubiquitination."
35636015
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"Thus, we speculated that the inhibition of USP7 could lead to the downregulation of AMBRA1 expression, reducing the competitive binding of AMBRA1 to NRF2 and enhancing DUB3‐mediated NRF2 deubiquitination, thereby alleviating intestinal inflammation."
39887666
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"21 , 65 , 66 Additionally, H O promoted the deubiquitination of AMBRA1 by USP7 in the nucleus, antagonizing DUB3‐mediated NRF2 deubiquitination and stabilization."
39887666
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"Taken together, our findings revealed that AMBRA1 plays a critical role in antagonizing DUB3‐mediated NRF2 deubiquitination, thereby promoting NRF2 degradation and aggravating oxidative stress (Figure 8 )."
39887666
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"By conducting transfection of epitope-tagged DUBs and examining the level of NRF2 by Western blotting, it was demonstrated that DUB3 directly binds to and deubiquitinates NRF2."
32360363
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"A recent study reported that DUB3 stabilizes NRF2 via deubiquitination of NRF2."
39887666
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"Consistent with these observations, AMBRA1 overexpression attenuated NRF2 deubiquitination and stabilization by DUB3, whereas AMBRA1 knockdown promoted the DUB3‐mediated deubiquitination and stabilization of NRF2 (Figure 3D,E,G,H)."
39887666
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"DUB3 deubiquitinates and stabilizes NRF2 in chemotherapy resistance of colorectal cancer."
30778200