IndraLab

Statements

COPS6 leads to the ubiquitination of HMGCS1. 4 / 4
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"Importantly, CSN6 KD efficiently increased the polyubiquitination level of HMGCS1 (Figure 4C), while CSN6 overexpression reduced HMGCS1 polyubiquitination (Figure 4D)."
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"Under physiological condition, Csn6 liver cancer tissue demonstrated higher SPOP expression, less expression of MDM2, HMGCS1 and survivin (YAP1 target gene) when compared with Csn6 liver cancer tissue (Figure 6J,K), suggesting that CSN6‐MDM2 axis‐mediated SPOP ubiquitination and consequential HMGCS1 stabilization can be recapitulated in Csn6 mouse liver cancer.2.7 Targeting CSN6-HMGCS1 Axis to Suppress Tumor Growth in NAFLD Related HCC."
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"Taken together, these data showed that CSN6‐HMGCS1 axis regulates mevalonate metabolism, promoting YAP1 nuclear translocation and transcriptional activity to facilitate tumor progression.2.4 CSN6 Promotes HMGCS1 Stabilization by Attenuating HMGCS1 Ubiquitination."
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"Thus, CSN6 antagonizes SPOP‐mediated HMGCS1 polyubiquitination.2.6 CSN6-MDM2 Axis-Mediated SPOP Ubiquitination."
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