IndraLab

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USP2 activates extracellular matrix. 4 / 4
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"Taken together, these data suggest that pharmacological inhibition of USP2 prevents dysregulation of ECM and promotes the integrity of the epithelial barrier in the gut during inflammation, and that targeting USP2 might provide a potential strategy for therapeutic intervention of inflammatory diseases in the gut.3 Discussion."
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"In addition, results from Masson trichromatic staining showed that collagens (major components of ECM in the gut) (Rieder et al., 2013) accumulated more intensively in the colon tissues from Usp2 mice than Lyz2-Cre;Usp2 mice after colitis induction (Fig. 5D), indicating that knockout of USP2 impairs the ECM remodeling in the colon inflammation."
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"These data together suggest that knockout of USP2 in myeloid cells inhibits dysregulation of ECM in the colon after DSS treatment.To further confirm that the myeloid cells trained the epithelium to induce dysregulation of ECM, we isolated RFP  cells from the LPMCs of Lyz2-Cre;Usp2 Ai14 mice Lyz2-Cre;Ai14 mice that were treated with DSS and cultured these cells for 18 h."
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"In addition, knockout of USP2 in myeloid cells inhibits the production of pro-inflammatory cytokines to relieve the dysregulation of extracellular matrix (ECM) network and promote the gut epithelial integrity after DSS treatment."
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