IndraLab

Statements

Cif inhibits USP10. 7 / 7
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"Cif inhibited ubiquitin specific protease 10 (USP10), a deubiquitinating enzyme, resulting in increased poly-ubiquitination and proteasomal degradation of TAP1."
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"Using this assay, we demonstrated that USP10 activity was inhibited 49 +/-4% by Cif (XREF_FIG)."
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"These data are consistent with the view that Cif reduces USP10 activity and thereby increases the amount of multi ubiquitinated CFTR and its degradation in the lysosome."
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"For example, in this and a previous study we observed that neither USP34, nor USP8 deubiquitinate CFTR, and only USP10 activity was inhibited by Cif XREF_BIBR, XREF_BIBR."
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"Cif inactivates USP10 in the early endosome."
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"If G3BP1 knockdown prevented the Cif mediated inhibition of USP10 activity, we would predict that knockdown of G3BP1 would also eliminate the increase in multi ubiquitinated CFTR and degradation of CFTR induced by Cif."
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"The next set of experiments was designed to elucidate how Cif inhibits USP10 activity."
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