IndraLab

Statements

Cif inhibits USP10. 8 / 8
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"Cif inactivates USP10 in the early endosome."
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"Using this assay, we demonstrated that USP10 activity was inhibited 49 +/-4% by Cif (XREF_FIG)."
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"These data are consistent with the view that Cif reduces USP10 activity and thereby increases the amount of multi ubiquitinated CFTR and its degradation in the lysosome."
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"The next set of experiments was designed to elucidate how Cif inhibits USP10 activity."
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"Pseudomonas aeruginosa secretes the bacterial toxin Cif, which inhibits USP10, leading to decrease USP10-mediated deubiquitination of CFTR and increase CFTR degradation in lysosomes, causing the weaker mucociliary clearance and the harder removal of pathogens to cure pneumonia (38)."
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"Cif inhibited ubiquitin specific protease 10 (USP10), a deubiquitinating enzyme, resulting in increased poly-ubiquitination and proteasomal degradation of TAP1."
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"If G3BP1 knockdown prevented the Cif mediated inhibition of USP10 activity, we would predict that knockdown of G3BP1 would also eliminate the increase in multi ubiquitinated CFTR and degradation of CFTR induced by Cif."
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"For example, in this and a previous study we observed that neither USP34, nor USP8 deubiquitinate CFTR, and only USP10 activity was inhibited by Cif XREF_BIBR, XREF_BIBR."
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