IndraLab

Statements

UCHL3 binds lsh. 4 / 4
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"In addition, the disturbance of the interaction between UCH-L3 and LSH by the long non-coding RNA GIAT4RA affects this progression [ 116 ]."
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"While LncRNA GIAT4RA attenuates the binding of UCHL3 to LSH and thereby suppressing the dubiquitiantion of LSH, leading to its reduction and ultimately inhibiting the progression of NSCLC [ xref ]."
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"Interestedly, LncRNA GIAT4RA binds to 227–589 AA of LSH, which disturbs the binding of UCHL3 to LSH, therefore repressing protein levels of LSH by counteracting its deubiquitination."
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"However, HOTAIR was also reported to reduce the ubiquitination degradation of AR by preventing its combination with MDM2, and GIAT4RA was recently reported to interfere the interaction between Uchl3 and LSH to repress ubiquitin-proteasome pathway [ xref ], which indicate multiple roles of lncRNA in ubiquitination."
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