IndraLab

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USP25 activates DNA-templated transcription. 7 / 7
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"USP21 activates transcription initiation by releasing H2Aub-mediated repression thus allowing methylation of H3K4."
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"USP21 binds to the promoter of IL-8 and promotes its transcription by decreasing H2Aub with concomitant H3K4me3 elevation (Peng et al., 2016a)."
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"USP21 is found to activate transcription initiation using in vitro reconstituted chromatin [14,44,45] ."
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"Moreover, USP25 is upregulated by lipopolysaccharide (LPS) and thus ubiquitination of histone acetyltransferase HBO1 is suppressed, resulting in altered gene transcription (49)."
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"We identified that USP21 deubiquitylates nucleosomal ubH2A in the nucleus and activates transcription XREF_BIBR."
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"In our study, the result confirmed that knockdown of USP21 negatively regulated the expression levels of cell stemness-related proteins, such as Oct4, Nanog, and Sox2, suggesting that knockdown of USP21 inhibited the stemness profiles of nasopharyngeal carcinoma cells.FOXM1 is a member of the Forkhead transcription factor family, which is a family of proteins with a helix DNA domain [15]."
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"For example, USP21 is critical for maintaining the undifferentiated state of mESCs by deubiquitinating Nanog and facilitates chromatin remodeling by Nanog to stimulate gene transcription (22)."
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