IndraLab

Statements

BAP1 activates TP53. 4 / 4
| 4
reach
"For example, p53 and BRCA1-related protein 1 (BAP1) induce ferroptosis in tumor cells through multiple signaling pathways, which act as a natural barrier to cancer development (5, 6)."
38125948
reach
"The upregulation of BAP1 expression can additionally augment the activity and stability of P53, thereby facilitating neuronal apoptosis and exacerbating neurological dysfunction after SAH ."
40274967
reach
"However, restoring BAP1 in p53 deficient cells still inhibited SLC7A11 expression (XREF_SUPPLEMENTARY - XREF_SUPPLEMENTARY), and the fold change in SLC7A11 expression by BAP1 restoration in p53 deficient cells was similar to that in p53-proficient cells (XREF_SUPPLEMENTARY), suggesting that BAP1 represses SLC7A11 expression independent of p53."
30202049
reach
"In addition, BAP1 overexpression enhanced P53 activity and stability by reducing P53 proteasome-mediated degradation."
38965653