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ATXN3 increases the amount of TP53. 2 / 2

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"One can hypothesize that SCA3 and other neurodegenerative disorders involve a positive feedback between proteasomal degradation, aggregation, GSK3 activation, and increased p53 levels."

33741019

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"Deletion of ATXN3 resulted in destabilization of p53, whereas ectopic expression of ATXN3 induced expression of p53 target genes and promoted p53-dependent apoptosis."

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IndraLab

Statements

ATXN3 increases the amount of TP53. 2 / 2

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